By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Board on Chemical Sciences and Technology, Committee on the Design and Evaluation of Safer Chemical Substitutions: A Framework to Inform Governme
Traditionally, laws governing chemical use have usually fascinated by wide-spread chemical substances and acute human healthiness results of publicity to them, in addition to their capability to reason melanoma and different antagonistic well-being results. As medical wisdom has multiplied there was an elevated understanding of the mechanisms in which chemical substances might exert destructive results on human well-being, in addition to their results on other species and ecosystems. identity of high-priority chemical substances and different chemical substances of shock has caused an increasing number of kingdom and native governments, in addition to significant businesses, to take steps past present detrimental chemical federal laws. curiosity in techniques and rules that make sure that any new elements substituted for chemical compounds of shock are assessed as conscientiously and carefully as attainable has additionally burgeoned. The overarching target of those methods is to prevent regrettable substitutions, which take place whilst a poisonous chemical is changed through one other chemical that later proved mistaken due to patience, bioaccumulation, toxicity, or different issues. Chemical substitute tests are instruments designed to facilitate attention of those components to help stakeholders in deciding on chemical substances which could have the best probability of injury to human and ecological overall healthiness, and to supply information on how the may perhaps boost and undertake more secure possible choices. A Framework to lead number of Chemical choices develops and demonstrates a choice framework for comparing possibly more secure replacement chemical substances as essentially made up our minds by means of human wellbeing and fitness and ecological dangers. This new framework is trained through prior efforts by way of regulatory firms, educational associations, and others to increase replacement evaluate frameworks which may be operationalized. as well as risk checks, the framework contains steps for life-cycle pondering - which considers attainable affects of a chemical in any respect phases together with construction, use, and disposal - in addition to steps for functionality and financial checks. The record additionally highlights how glossy details assets corresponding to computational modeling can complement conventional toxicology information within the evaluation technique. This new framework permits the evaluate of the complete diversity of advantages and shortcomings of substitutes, and exam of tradeoffs among those dangers and components equivalent to product performance, product efficacy, procedure defense, and source use. via case reports, this document demonstrates how diverse clients in contrasting selection contexts with assorted priorities can follow the framework. This document can be an important source to the chemical undefined, environmentalists, ecologists, and kingdom and native governments. Read more...
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Extra info for A framework to guide selection of chemical alternatives
Sustainable Production’s Alternatives Assessment Framework (Rossi et al. S. Environmental Protection Agency Design for the Environment program’s Alternatives Assessment framework (EPA 2014c); the United Nations Environment Program Persistent Organic Pollutants Review Committee’s “General guidance on considerations related to alternatives and substitutes for listed persistent organic pollutants and candidate chemicals” (UNEP 2009); the methodology derived from the University of Massachusetts at Lowell’s Toxic Use Reduction Institute’s (TURI) 2006 Five Chemicals Alternatives Assessment study (TURI 2006a); and the Interstate Chemicals Clearinghouse’s (IC2) Safer Alternatives Assessment Wiki (IC2 2014).
In Chapter 12, two examples of how to implement the committee’s thinking are presented in an alternatives analysis of glitazone and decabromodiphenyl ether. Finally, Chapter 13 describes innovation in process and chemical design, including specifics on how to consider properties upfront when developing new chemical entities. Appendix A provides biographic information on the committee. Appendix B accompanies Chapter 6 and provides an overview of how other frameworks considered ecotoxicity. Appendix C describes the visualization tool ToxPi.
This step aligns the committee’s framework with several other frameworks with regard to this concern. In addition, this step is intended to determine whether human health, environmental, and social equity impacts might occur at a place or time other than the point of use of the chemical of concern. This consideration will serve to determine whether additional assessments are required to compare alternatives. IC2, BizNGO, and the German Guide evaluate whether life cycle concerns indicate a need for a more formal life cycle assessment.
A framework to guide selection of chemical alternatives by National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Board on Chemical Sciences and Technology, Committee on the Design and Evaluation of Safer Chemical Substitutions: A Framework to Inform Governme