By Anthony Koleske
Abl kinfolk Kinases in improvement and sickness presents an summary of the features of Abl kinfolk kinases in improvement and affliction. This new name discusses the biochemical, genetic, and telephone organic facts that elucidate the mobile roles for those kinases in those tactics.
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Additional info for Abl Family Kinases in Development and Disease (Molecular Biology Intelligence Unit)
In recent unpublished studies, we have examined the pro-death function of Abl proteins that are either exclusively cytoplasmic (NLS-mutated), exclusively nuclear (Nuc), or shuttling (wild type). ^ W h e n expressed in an appropriate cell context, dimerization of wild type or Abl-Nuk is sufficient to activate programmed cell death (XD Huang and JYJ Wang, unpublished). However, dimerization of cytoplasmic Abl does not initiate cell death (XD Huang and JY] Wang, unpublished). This result demonstrates the requirement for Abl nuclear import in the induction of apoptosis.
Integrins may also utilize Abl family kinases to regulate nuclear processes such as gene expression, cell cycle progression and cell survival. However, much remains to be learned about the biochemical mechanisms whereby Abl family kinases link integrin receptors to downstream cellular responses and about the physiological consequences of these signaling events. A comprehensive understanding of the cell adhesion responses mediated by Abl family kinases and their biological significance requires the completion of several future challenges.
Oncogene 2002; 21 (56):8612-8628. 15. Gordon MY, Dowding CR, Riley G P et al. Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia. Nature 1987; 328(6128):342-344. 16. Verfaillie C M , McCarthy JB, McGlave PB. Mechanisms underlying abnormal trafficking of malignant progenitors in chronic myelogenous leukemia. Decreased adhesion to stroma and fibronectin but increased adhesion to the basement membrane components laminin and collagen type IV.
Abl Family Kinases in Development and Disease (Molecular Biology Intelligence Unit) by Anthony Koleske