By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels
This ebook is the 7th quantity within the sequence "Acute publicity instruction degrees for chosen Airborne Chemicals", and comprises AEGLs for acetone cyanohydrin, carbon disulfide, monochloroacetic acid, and phenol. on the request of the dept of safety, the nationwide examine Council has reviewed the proper medical literature compiled through a professional panel and proven Acute publicity guide degrees (AEGLs) for 12 new chemical substances. AEGLs signify publicity degrees lower than which opposed health and wellbeing results are usually not more likely to take place and are helpful in responding to emergencies comparable to unintentional or intentional chemical releases in the neighborhood, the office, transportation, the army, and for the remediation of infected websites. 3 AEGLs are licensed for every chemical, representing publicity degrees that lead to: remarkable yet reversible ache; long-lasting future health results; and, life-threatening well-being affects.
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Extra resources for Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 7
The activity of rhodanese is variable between species and tissues but is high in liver and kidney in most species (Ballantyne and Marrs 1987). C. 2), which is found in blood, liver, and kidney and catalyzes the transfer of a sulfur atom from 2-mercaptopyruvate to cyanide forming pyruvate and thiocyanate, is not known (DECOS 1995). The halflife time for the conversion of cyanide to thiocyanate from a nonlethal dose in humans is between 20 and 60 min (ATSDR 1997). A minor pathway for cyanide detoxification is the formation of 2aminothiazoline-4-carboxylic acid from cyanide and cystine.
6 2h LC30 Izmerov et al. 1982 cyanohydrin or to the normal variation in experimental animals of the same strain. 4 ppm). 2. Mice Gabor et al. 5-3 mg/L [40-840 ppm]) for 2 h. Deaths were reported as 0 of 10 mice at 140 ppm, 0 of 10 at 280 ppm, 8 of 10 at 420 ppm, 18 of 44 at 560 ppm, 4 of 10 at 700 ppm, and 10 of 10 at 840 ppm. 05 mg/L (574 ppm). The mouse strain, analytic methods, and post-exposure observation period were not reported. Izmerov et al. 6 ppm) for 2 h in mice (no details were reported).
Once absorbed, a dose of acetone cyanohydrin behaves in a manner identical to that of its molar equivalent in absorbed free cyanide. It is appropriate to apply the AEGL-1 values (on a ppm basis) derived for HCN (NRC 2002) to acetone cyanohydrin. This procedure is supported by similar values that would be derived on the basis of available acetone cyanohydrin studies in rats. 2 ppm for 6 h/d, 5 d/wk for 4 weeks, which did not result in red nasal discharge (Monsanto 1986a). 69 ppm would be derived for the 10- and 30-min and 1-, 4-, and 8-h periods, respectively.
Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 7 by National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels