By C. Weissmann (auth.), Manuel J. T. Carrondo, Bryan Griffiths, José L. P. Moreira (eds.)
Animal cellphone expertise has passed through a quick transformation over the past decade from a examine device and hugely specialized know-how to a valuable source for innovation in pharmaceutical examine and improvement. those lawsuits of the 14th assembly of the ecu Society for Animal mobilephone know-how (Vilamoura, Portugal, may perhaps 1996) increase to this point the ancient viewpoint of animal mobile expertise for the good thing about society, `From Vaccines to Genetic Medicine', and should constitution this very important know-how for the future years.
robust contributions are grouped within the conventional ESACT parts of 'Cell and body structure Engineering' facing phone kingdom, together with genetics, and its setting, and 'Animal phone approach Engineering' protecting integration of bioreaction with bioseparation coupled with online tracking to enhance protein creation and consistency. vast insurance of metabolic engineering on synthesis, folding, meeting, transiting and secretion is handled within the consultation on 'Recombinant Proteins: Biosynthesis and Bioprocessing'. conventional yet increasing parts of animal mobilephone expertise relevance are highlighted within the wide classes of 'Animal Cells as instruments for Discovery and trying out' and 'Animal cellphone Vaccines: current and Future'. classes eventually disguise the more moderen domain names of animal phone know-how paintings - 'Tissue Engineering and Biomedical units' and 'Cells and Vectors for Genetic drugs' - the place you can still foresee a really vivid future.
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Additional info for Animal Cell Technology: From Vaccines to Genetic Medicine
Despite the variation in surface expression among the WSXWS mutants, all mutant receptors that reached the cell surface bound and internalized EPO normally, and were able to transmit a proliferative signal. These results suggest that the WSXWS motif plays a crucial role in generating a correctly folded receptor which is competent to exit the ER and be transported to the cell surface. The two subtypes of the H2 subunit of the asialoglycoprotein receptor, H2a and H2b, a galactose specific C-type lectin, differ only by a pentapeptide insertion in 22 the exoplasmic juxtamembrane region of H2a.
Schleuning: No, it is fluorescent in the absence of the ligand. It is biologically fully active. Hauser: Was the full receptor moiety used or only the C. terminal part? Schleuning: No, we used it on the C. terminal part. Bernard: Is the GFP fluorescence dependent on the environmental conditions and physiological state of the cells? Schleuning: Yes, at least the conventional GFP does not work very well in animal cells but there are mutations which are functioning and giving a better signal noise ratio.
21. , T. Zimmers, D. Neumann, G. Longmore, Y. Yoshimura, and H. F. Lodish. 1992. Mutations in the trp-ser-X-trp-ser motif of the erythropoietin receptor abolish processing, ligand binding, and activation of the receptor. J. BioL Chem. 267:11619-11625. 22. Yule, M. , and H. F. Lodish. 1993. Two pathways for the degradation of the H2 subunit of the asialoglycoprotein receptor in the endoplasmic reticulum. J Cell Biol. 123:1735-49. 23. Yuk, M. , and H. F. Lodish. 1995. Enhanced folding and processing of a disulfide mutant of the human asialoglycoprotein receptor H2b subunit.
Animal Cell Technology: From Vaccines to Genetic Medicine by C. Weissmann (auth.), Manuel J. T. Carrondo, Bryan Griffiths, José L. P. Moreira (eds.)