Home Nonfiction 10 • Download e-book for iPad: Antihypertensive Drugs Today by G. L. Wollam, R. W. Gifford Jr., R. C. Tarazi (auth.), R. N.

Download e-book for iPad: Antihypertensive Drugs Today by G. L. Wollam, R. W. Gifford Jr., R. C. Tarazi (auth.), R. N.

By G. L. Wollam, R. W. Gifford Jr., R. C. Tarazi (auth.), R. N. Brogden (eds.)

ISBN-10: 0959982760

ISBN-13: 9780959982763

ISBN-10: 9401172684

ISBN-13: 9789401172684

ISBN-10: 9401172706

ISBN-13: 9789401172707

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Following acute and chronic administration, prazosin lowers arterial pressure by decreasing peripheral vascular resistance and cardiac output is usually unchanged or slightly increased (Lund-Johansen, 1975). Because of the relaxant effect on venous capacitance vessels, prazosin may cause a reduction in venous return to the heart. , 1978). , 1977). , 1977). 2 Pharmacokinetics The pharmacokinetics of prazosin are not well understood. , 1976); however, its therapeutic action does not appear to be closely related with plasma levels (Collins and Pek, 1975).

1 Mode of Action Clonidine is a centrally acting sympatholytic agent with antihypertensive potency comparable to that of methyldopa (Putzeys and Hoobler, 1972). Pharmacologically, clonidine is an a-adrenoceptor agonist and lowers blood pressure by stimulation of post-synaptic a-adrenoceptors· in the vasomotor centres of the medulla (Haeusler, 1975; Kobinger, 1976). This results in inhibition of sympathetic outflow from the central nervous system and enhanced vagal stimulation, which presumably results from facilitation of the pressure sensitive baroreceptor reflex by the action of clonidine (Kobinger, 1975, 1976).

The hearing loss can be associated with tinnitus or vertigo and most often occurs following the parenteral administration of large doses of ethacrynic acid or frusemide to patients with renal insufficiency. , 1973). Antihypertensive Drugs II 2. 1 Ganglionic Blocking Agents The significance of the ganglionic blocking drugs is probably of more historical than practical importance. With the availability of sodium nitroprusside and drugs which selectively inhibit the adrenergic nervous system, these agents are seldom, if ever, used.

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Antihypertensive Drugs Today by G. L. Wollam, R. W. Gifford Jr., R. C. Tarazi (auth.), R. N. Brogden (eds.)

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